@GreyTechnician I don't think Lemmy is really interested in that sort of thing or at least not the Karma stuff as it really get's toxic quick between users. If you like the idea of Karma there's Kbin / Mbin instances that have reputation that is the same thing.
When it comes to bots though there's not much you can do other than tell the admin of the instance to block them out. If they are running on another instance such as I'm on the Kbin.run instance then the admin can straight block that whole instance if it's just full of bots. So really it can only be sorted with moderation.