American Dad, starting at season 2, is complete gold.
The first season is rough, since the political comedy elements aren’t quite finetuned, which makes the characters a bit annoying, and Roger doesn’t have wacky disguises yet. Season 2 onwards the show has just right right wavelength of bizarre non-sequitur humor that always makes me smile. The jokes can be dark and/or adult, or just require context to understand but I think they are great.