Nerve Damage, a game that was I think made on a random gamejam, and the whole premise is to make a game that’s actively trying to be as uncomfortable as possible to play, while also getting you into the flow and actually makes you enjoy it.
Unfortunately, I didn’t find how to play it, and it didn’t release as far as I know. I’ve heard about it on some kind of GDC presentation about Innovative/Obscure game design.
While that actually means that someone has indeed heard of, I’ve never met anyone else who got to play it. Or heard about it.