When you are at the brain stem leading to the final fight if you have Gale in your party you can skip the entire final fight. Just send Gale up alone and he will confront the brain by himself leaving everyone else alive. This kills Gale so if he is your husbando you have a tough decision to make.
Tough decisions are for after you’ve gotten the golden d20. My current run though I’m mercenary as hell. I ate all the worms even the astral worm with gusto. I’ll be a mind flayer, murder Isobel, whatever. I might let the hag eat Vanya to have her as an ally in the final fight.
The only things I haven’t done are the ones that relied on dice rolls that I failed. I gave up the hag bonus the first time in favor of keeping Marina alive, but I also couldn’t think of a stat that could really benefit. I almost took it so that my charisma could stay 8 with the smuggler’s ring but ultimately decided that wasn’t worth letting Ethel have her.
I lucked out with the zathisk and book of Thay. Misclicks are the worst. “Hey bro, what’s up? Whoa! I didn’t mean to touch the carrot! [Deception] Oh I already had that on me. [Critical Failure].” A short combat later. “Fuck!”