Nobara KDE user here. One of the reasons why I chose it is because it comes with many of the customisations that I’d normally do (such as using an optimized kernel). But in addition, I use:
Opal instead of LUKS
KDE configured with a more GNOME/macOS like layout (top panel+side dock)
GDM instead of SDDM, for fingerprint login
Fingerprint authentication for sudo
TLP instead of power-profiles-daemon for better power saving (AMD P-State EPP control, charging thresholds etc)