For fileservers ZFS (and by extension btrfs) have a clear advantage. The main thing is, that you can relatively easily extend and section off storage pools. For ext4 you would need LVM to somewhat achieve something similar, but it’s still not as mighty as what ZFS (and btrfs) offer out of the box.
ZFS also has a lot of caching strategies specifically optimized for storage boxes. Means: it will eat your RAM, but become pretty fast. That’s not a trade-off you want on a desktop (or a multi purpose server), since you typically also need RAM for applications running. But on a NAS, that is completely fine. AFAIK TrueNAS defaults to ZFS. Synology uses btrfs by default. Proxmox runs on ZFS.