That’s pretty much what I do as well. It was an absolute game-changer for me when I discovered tiling WMs some ~7 years ago, because it meant super consistent keyboard shortcuts for getting to exactly what I wanted to interact with. I know where individual apps/tasks go, so I put them there. And then when I need to switch to them, it’s as straightforward as Super+[workspace].
Also helps a ton that i3wm’s workspaces only take up a single monitor at a time, which makes it excellent for jumping between monitors.
None of this is set in stone, but I usually follow a relatively consistent pattern:
Center Monitor
1: Primary/“serious tasks” web browser
4: Any remote or virtualized desktop I might have open at the time
6: Image/video editors. Also sometimes just misc usage.
8: Development web browser next to neovim
9: Steam/games
10: Misc. Often a DBMS or file manager
11: Misc. Often where I put any secondary tasks or second projects I need to reference
12: Misc. Often where I’ll stick any long-running tasks that I just need to check on every now and again.