I guess I’m open minded because I’m a noob with Linux yet I’ve worked with XFCE, LXQt, KDE, and GNOME (in that order), and none of them were a pain, except possibly LXQt, which was super clunky to customize, but it ran amazing on weak hardware, so I’m giving it a pass. I reckon I’d be cool with Cinnamon, MATE, Unity, or even one of the lightweight DE’s.
Yet, all of these DEs I’ve used were on Ubuntu based distros. I feel afraid to encounter weird things with other distros. For example, doesn’t DaVinci Resolve only run on Ubuntu based distros?