Btw dev mode is officially support by LG and is not “patched” out. Maybe you mean the unofficial root exploit?
And yes developer mode does need to be refreshed but I believe once you have a custom app sideloaded then you may not need to refresh it. At least I haven’t needed to refresh it or even have the dev mode app continue to be installed. The “refresh” is to keep the connection to your computer open which isn’t needed.