If it’s not been used, there should be no major difference. That’s a big IF though. There’s lots of resellers on NewEgg and Amazon that sell “refurbished” drives with a BS warranty of 30-90 days, after which the drives will more than likely fail. Most of these resellers reset the SMART data to report a drive as passing, or go so far as to swap controller boards to make it seem new. Do your research before buying.