I don’t (generally) sail the high seas, but I’m surprised that people don’t use SysInternals tooling on windows. Of note:
ProcExp - A way better process explorer and has a built-in VirusTotal scanner for all running processes. 100 times better than standard process explorer. This in combination with windows defender is nearly always enough.
AutoRuns - A tool to see what automatically runs on your system. Included image hijacks and such. This is for handling potential post-infection scenarios.