I do this and it works great. Ad block on all my devices regardless of proprietary sandboxes. I also use Syncthing over my tailnet IP addresses so that traffic never leaves my “grounds”. I’m slowly building out a whole suite of services I host only within my tailnet, jellyfin, calibre, invidious, it been a great learning experience. I’m about to set up a proper home lab, finally moving everything off an old laptop.