GrapheneOS has been basically flawless for me, most of the time I forget I’m even using a custom rom. Using the Aurora Store, along with a few select apps in a work profile with sandboxed Google Play services goes a long way in terms of plugging the usability gap. I know there’s supposed to be issues with banks, but at least in my anecdotal experience, I’ve used accounts from 3 different banks and haven’t had any issues.
NVIDIA’s Debian repo for Cuda has more up to date GPU drivers, if you don’t wanna manually install from the .run file. Documentation here, its not reflected yet in the docs but there’s a Debian 12 repo.