My dad was allergic to practically every antibiotic. He only developed the allergy in his senior years. It was a big problem for him. Even if the antibiotic seemed to be working okay, he had to take a lot of Benadryl just in case and keep an epi pen around.
Thankfully, my mother doesn’t seem to have this problem. She’s 81, so if she hasn’t developed it yet, I don’t think she’s going to. Really sucked for my dad though.
On Thursday afternoon a stabbing incident in Dublin saw three children and an adult injured near a school, which some people blamed on the government’s immigration policy.
Police say right-wing agitators were behind violent protests which followed the stabbing, bringing angry mobs onto the streets of the city centre, burning vehicles and smashing windows amid a wave of anti-immigrant sentiment.
I have my suspicions about where Musk’s sympathies lie.
Bacteriophages are a great secondary option. Similar to how bacteria quickly evolve resistance to antibiotics, bacteriophages can quickly evolve to circumvent phage resistance.
Does this AI use the same process for piecing together things as LLMs do for art and writing? Is this a drug we have known about but not yet applied as an antibiotic or a whole new compound?
It doesn't sound like it but they don't have enough detail in the article to say.
It sounds likey they are using a classification model that takes a vectorized text representation of molecules and classifies or scores them by their expected properties/reactivity. They took 39,000 molecules with known reactivity to MRSA to train the model, I assume to classify the structures. Once trained they can feed in arbitrary molecules into the trained model and see which ones are predicted to have antibiotic properties, which they can verify with bench work.
They likely fed in molecules from classes of likely candidate structures, and the model helped focus and direct the wet work.
I'm not up on the latest, but years ago I helped a similar project using FPGAs running statistical models to direct lab work.
This was years ago before GPU processing really took off, and we wanted the performance, but also, wanted to see if we could develop an affordable discrete lab device that could be placed in labs to aid in computationally directed bench work. So effectively, testing the efficacy of the models and designing ASICs to perform lab tests.
With a CPU or even a GPU, there is a bunch of inefficiencies for every task as they’re designed to be able to do pretty much anything - your H265 media decoder isn’t going to be doing much when you’re keeping a running sum of the number of a certain type of bond in a list of chemicals
With ASICs and a lesser extent FPGAs, you can make it so every single transistor is being used at every moment which makes them wildly efficient for doing a single repetitive task, such as running statistical analysis on a huge dataset. This is because rather than being limited by the multiprocessing ability of the CPU or GPU, you can design the “program” to run with as much multiprocessing ability as is possible based on the program, meaning if you stream one input per clock cycle, after a delay you will get one input per clock cycle out, including your update function so long as it’s simple enough (eg moving average, running sum or even just writing to memory)
This is one specific application of FPGAs (static streaming) but it’s the one that’s relevant here
So it sounds like we’re designing the instruction pipeline for maximum parallelism for our task. I was surprised to learn that the first commercial FPGAs were available as early as the '80s. I can see how this would have been an extremely effective option before CUDA became available.
llms have progressed beyond cut and paste way more than a year ago. they have shown understanding of what items are and how they behave and interact. I know it’s popular here to call it a parrot or whatever but most people don’t have access to the high level stuff and most seem afraid/snobby/parroting things themselves.
Virtual screening libraries are usually some form of expanded chemical space meaning they contain real and previously unknown compounds. The article says the 12 million compounds screened virtually were commercially available, but I couldn’t see enough of the nature paper to verify. It could be that the virtual screening set was acquired from a private company, but that doesn’t necessarily mean all the compounds are known.
I saw the source was Euronews and my first thought was, “I wish we could have this in America.” And what do you know? It is here! Not surprised that California is leading the way. I hope this develops more broadly over time. We desperately need a modern rail system.
Same over here in europe. The train system we have over here is anything but perfect. Every country or region still has different standards, requiring a change if wheels, connectors and other parts on the route of a long-distance train. This costs a lot of money too. Train tickets are soaring. Train routes are clogged. Short distance trains are partly being closed, shortened or showing their age. Despite an increase of flight ticket prices, people still find flying more compelling than travelling by train.
Still, night trains are somewhat having a little revival right now.
I really hope we can get some fresh new wind and new tech. It is time our Transport Tycoon enters the future era ;)
What’s so annoying about this is that it’s so opportunistic and it’s a template we see the far right using in a lot of other places too. None of these people rioting care about the victims, they just want to create a bunch of xenophobic violence and fear.
The article says this holly was ranked highly on a list of lost plants that scientists hope to rediscover. Does anyone happen to know why this particular species ranked so highly? I know many hollies have medicinal or edible properties, and many provide food for wildlife, especially birds. But does this one have anything particularly notable, like how Ilex vomitoria and Ilex paraguariensis contain caffeine?
No matter the answer, it’s very cool this was rediscovered
Mastodon has user defined word filters, you can completely mute this crap (of course people love misspelling his name).
I wish lemmy/kbin would get something similar it's really annoying to have this fucker in my feed daily.
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