I think there’s definitely something healthy behind the idea that depression is actually a fairly natural or reasonable state, however hard and painful it can be. Especially for anyone that wants to be mindful of the danger of psychopaths or sociopaths who are probably the types of people that seem oddly immune or unable to understand or empathise with depression.
Otherwise, I’ll just say that a “second childhood” can be a thing (as far as I can tell), where all of the concerns of middle age fade away and we’re forced to wrestle, naively perhaps, with the sheer reality of existing.