Hardware is 5950x, 64gb ram and a 4090. Although before I had a 3070 Ti.
I’m on Arch, but what problems are you having with proton or Lutris? Which Nvidia drivers do you have installed (dkms?) and what kernel?
With the state of proton, I almost never have to check the force compatibility tool and select a version, it’ll work out of the box. There have been a few exceptions of course.