Crohns as well and infliximab the immunomodulator has basically had me in clinical remission after surgeries. For me it doesn’t seem to be psychologically related or even diet, given that I don’t just eat hot spicy foods constantly, but I eat all the “bad” foods and tolerate fiber etc. The microbiome thing seems to make sense in my case, I’ve had one significant flare in the last decade and it definitely had that feeling of a runaway feedback loop of inflammation. Infliximab basically binds to those inflammatory proteins and cuts that loop.