Dev work is not specific enough. Pip is a nightmare because it just wanted to modify folders that were read only and you never know what it wants to do to your system. Your experience may vary depending on how much the language package manager assumes about your system. If you’re in a container, it will work perfectly, though
Firefox just works, and I installed Steam from nixpkgs and it worked after enabling a few settings. Then I just enabled Proton on every game and it works okay, with a few weird bugs sometimes (although I blame Gnome for messing up alt tabbing sometimes)