I use Mailcow and it works well. Easy to configure, and it uses Docker so it’s self-contained and very easy to move to a new server if you ever need to do that.
I’m using an SMTP relay for outbound emails, though. I didn’t want to have to deal with IP reputation issues, especially with Microsoft/Hotmail. I’m hosting my server on a VPS, and spammers in the same subnet can result in the entire subnet getting blocklisted. Configuring a relay is easy in Mailcow’s UI, and can be configured per domain.