Personally, I’ve relied on an OnlyKey for a few years (with backups and an extra fallback device) and haven’t needed to type passwords since. This doesn’t help with the number of prompts, but it does make them easier to dismiss.
I do use autologin, but I don’t use a system wallet (only KeePassXC, which I do need to unlock manually). Autologin with system wallets can be tricky, but I’ve had some luck setting it up in the past. You might want to check out this wiki for PAM configuration.