That depends which DLSS. In my testing DLSS 1 and 2 work fine in games that I tried, with recent Proton enabling it as well as ray tracing shouldnt require extra steps anymore (it was experimental and opt-in using environment variables). DLSS 3 with frame generation is known as no go yet and it’s unfortunately on NVIDIA to provide support for it as it’s very much locked down guarded proprietary stuff.