I had two 5 screens and two columns. One screen was for terminal emulators, one was for writing code and software development, one was for my web browser, 2 others were for miscelaneous things, but most often were for working with files a GUI file browser like Nautilus or Thunar, or for reading PDF files in Evince, or reading PowerPoint or Excel documents in LibreOffice.
On each screen the tiles were always in 2 columns. The left for doing work, writing code, prose, drawing graphics and charts, interacting with the CLI, and so on. On the right was documentation: manual pages, PDF files, HTML documents, sometimes the MPV video player window when watching a tutorial that I was able to download from YouTube.
The right column usually had no more than 3 windows open, they started to get too narrow to be useful if more than that were open. I would occasionally horizontally split the left column as well, usually when going back and forth between two documents I was editing.
However…
I did not use this workflow once I started using Tmux, and then I continued not using this workflow when I switched to Emacs. The reason is of course because Tmux and Emacs both provide their own tiling windowing system that operate within a single application window. So my main workflow was always in a single maximized terminal window, or a single maximized Emacs window, or a single maximized GIMP window. Only occasionally would I un-maximize these windows, but then to keep it from getting too small, I would set it in “floating window” mode. Also my web browser, PDF reader, GIMP, LibreOffice, all worked better in full-screen (maximized window) mode. Even Thunar (GUI file browser) has multiple tabs, and a multi-column mode which was useful for the very few times I ever needed a GUI file browser.
At one point, I actually changed my tiling window manager configuration to always open windows maximized, except for Thnuar (GUI file browser) which would open in floating mode, not tiling mode. At that point I finally realized that I don’t really using a tiling window manager at all, it is just there managing windows the same as a non-tiling window manager would do.
I switched back to the Xfce default window manager, and quit worrying about window managers all together.