Thanks for the advice! The application I’m using in Wine is Elite Dangerous Market Connector, nota game itself but a small helper app for the Elite Dangerous game. According to the git page, you can get it running from source with Python, but I wasn’t quite skilled enough to get that working.
As far as my actual games go, those seem to all run fine through Steam/Heroic Games Launcher with Proton GE edition, which as I understand it incorporates Wine somehow…? I’m not sure of the specifics, but I assumed Wine in that context would get updated with Proton eventually.