For mental health reasons, I had taken myself out of most political topics. But lately there seems to be a surge of talk about Palestine and Hamas (forgive me if I spelled this wrong). I do know it’s something to do with land rights, but it also seems to be so much more at the same time. I’m not trying to start any fights. I...
When writing basic business code, structuring the code well and having good naming standards means you shouldn't need a ton of comments, but you should still have some. Plus, using structured function content blocks gives you intellisense in some languages and IDEs, which is important for code reuse in teams.
However, when I was doing scientific programming I'd have comments for almost every line at times where I put the mathematical formula and operations the line represents. Implementing a convolution neutral network with parameters to dynamically scale the layers or MPI stochastic simulations is much different than writing CRUD functions or basic business logic.
It sounds like they are moving forward with clinical testing in partnership with a bio company, so I'm sure they withheld the information anticipating a patent. The results of this paper was the validation of the explainable AI model which identified candidate classes of compounds.
It sounds like they trained a classification model using 39,000 molecules with known reactivity to MRSA. The molecules are vectorized text representations of the structures. Once trained, they can run arbitrary molecules through the model and see which ones are predicted to have antibiotic properties, or at least MRSA reactivity.
They likely fed in molecules from families of structures that seem likely to contain an antibiotic but are too numerous to manually test them all. They get a prediction of which ones are likely to have the properties they want, and then start the slow process of creating and testing the molecules in the lab.
This was years ago before GPU processing really took off, and we wanted the performance, but also, wanted to see if we could develop an affordable discrete lab device that could be placed in labs to aid in computationally directed bench work. So effectively, testing the efficacy of the models and designing ASICs to perform lab tests.
It doesn't sound like it but they don't have enough detail in the article to say.
It sounds likey they are using a classification model that takes a vectorized text representation of molecules and classifies or scores them by their expected properties/reactivity. They took 39,000 molecules with known reactivity to MRSA to train the model, I assume to classify the structures. Once trained they can feed in arbitrary molecules into the trained model and see which ones are predicted to have antibiotic properties, which they can verify with bench work.
They likely fed in molecules from classes of likely candidate structures, and the model helped focus and direct the wet work.
I'm not up on the latest, but years ago I helped a similar project using FPGAs running statistical models to direct lab work.
I have an Excel workbook with three worksheets. One worksheet calculates my paydays out over the next few years, and using Excel formulas a table of paydays per month is calculated. I get paid every two weeks, so some months are 3 pay checks and the rest are 2. If you get paid a fixed amount per month it's easier.
The next sheet has tables for annual, monthly, and weekly expenses. The annual table has a column for month of the year. If I have a quarterly payment, I add it to the annual table four times, each with the correct month.
The final worksheet is a basic revenue less expenses table, one for each calendar year. It lists my income per month for each month, and then lists my monthly expenses, my annual expenses that hit that month, and weekly expenses calculated to reflect the partial weeks. All using formulas do it is easy to extend out to future years.
The worksheet also calculated how much I have left over, and what my savings target is (80% of unbudgeted funds). It's important for the actual costs of each month to be accurate, because averages hide real world things, like in November I have a large amount of renewals including my annual car insurance payment. I will always spend more than I make in November, and knowing that means I'm not panicking with unexpected expenses.
What I've found is that there is an art to budgeting. For example, I budget $100/month for discretionary purchases, plus $20/week to take my kids out for cocoa. You want to be specific enough in the budget that you have fairly few purchases not directly accounted for, with a little bit of latitude that it doesn't become a grind to track purchases.
Over the course of the month any purchase that exceeds the budgeted amount or that doesn't fit a budget category gets tracked on a separate sheet so I can see if I need to rebudget or if there was just a one time thing. Generally speaking, if it is too much work to track your individual purchases, you might be making too many small or impulse purchases that add up.
I also use Excel for my shopping lists to stay focused when I go to the store, and the mobile app easily lets me strike through items as I get them.
I got a task to buy a smart phone for my grandparents, they are not techsavy but they know how to use basic functions. Iam looking for an andoid because it has language pack i need. I dont need it to have lots of functions, onley a good camera and a big screen. Bonus points if it can be flashed with some kind of simplefied...
My advice is a little different than others. I recently got my in-laws outfitted with smartphones and a new nuc. My father in-law has Parkinson's, slow onset, but it means he is clumsy. It's not likely that his phone will survive shaky hands for 8 years. What I did was buy refurbished OnePlus phones, install a simple launcher, install Bitdefender, and then add a lock app that let's me add a pin to the system settings app and the play store.
They can't install anything out change things. They can browse, play games I preload, take pictures, etc, but I don't have to worry about them installing things they shouldn't. If one of the phone dies I'll just get the latest affordable refurbished of the same line and configure it the same way.
I had originally tried without locking the phone down as much but my father in law could not stop installing spammy weather apps and clicking ads on games and following there instructions.
I also created new Google accounts for them that I manage, so they can't get stuff stolen with bad account management practice.
If you are in the US, I've also found mint to be a good deal for cell service.
Hi, everybody Recently, a guy noticed that I was using it and asked why? For me it because in Linux many things are done through the terminal because Linux has many different desktop environments...
I use a terminal whenever I'm doing work that I want to automate, is the only way to do something such as certain parameters being cli only, or when using a GUI would require additional software I don't otherwise want.
I play games and generally do rec time in a GUI, but I do all my git and docker work from the cli.
I've been using Duolingo to learn Spanish, and there are a lot of things I dislike about it. However, credit where credit is due, I don't have a huge drive to learn but rather I'm opportunistically learning as I have time for self improvements sake. And for that, Duo does an ok job of feeding me new lessons and slowly expanding my knowledge of the language in a few minutes a day, and it's free. After about three months I can go to a Mexican cafe, get a table, ask about the servers day, and chit chat about my kids, all in Spanish.
Which, if I'm being honest with myself, is more than I would have gotten self studying.
Sure, the first year (or two) of COVID were wretched, but most of those barriers have since cleared — yet I’m still struggling. I’ve noticed the same with a number of people within my family and neighbourhood....
I guess "getting into Christmas" probably means something different to everyone. For me it's about reliving good memories of friends and family. Some of my favorite memories are decorating cookies with my kids, mixing batches fudge, sipping eggnog and coffee over pie and ice cream, or dancing with my kids to Christmas music.
So for Christmas I play Christmas music, setup a tree, make cookies and fudge, and send the treats and little mementos to friends and family around the country. This year I sent Christmas muffins, fudge, drawings my daughter made, little $1 bottles of peppermint schnapps with Cocoa packets, and other things like Santa socks that I divied up from a cheap multipack. That was the presents I sent out to all our friends and family.
But if I didn't have those memories or enjoy baking, I doubt I would do much for it. So I suppose, ask yourself what getting into Christmas means to you, or take the time to define what you want it to mean to you, and then do the thing. If it's taking a little bit of extra time to show family you are thinking of them, then a little home assembled Cocoa kit and a card might do it. You don't need to go crazy with decorations or buying presents to get into Christmas, unless that is what you want it to mean to you.
On Futurama one of the popular phrases from the character zoidberg was something like "hey, look it's me your nephew" when he thought his uncle was rich. Don't recall the details, but just riffed on the meme.
Everyone is different, and life is path dependent. Some people don't struggle with difficult memories, and others have simply not lived an unpleasant enough life to have accrued the emotional scars.
However, being blatantly brusque in your description of others followed by "sorry if I offended" is the epitome of ringing hollow. At least be honest; you don't care if you offended others.
Not all thoughts are consciously summoned, wanted, or pleasant. The term intrusive thoughts is a good way to describe those thoughts we find unpleasant. Yes, they are natural and normal, and often how we grapple with and process experiences, but that doesn't make them unobtrusive.
Additionally, many people have intrusive recollections of upsetting events from the past. Intrusive thoughts is a good descriptor that helps avoid over using terms like flashbacks or PTSD.
Clarifying such things as intrusive helps destigmatize these thoughts for people who have them and feel the weight of social expectations, like new parents as in the comic. Feeling guilty about having these thoughts isn't healthy, and properly describing them as unwanted helps people process them. I don't see what is particularly objectionable or hard to understand about the term and why being more specific in the description of one thoughts is off-putting to you.
I’ve never had a Facebook account or any other social media. I know they keep shadow profiles, but I’ve never given permission. I never had any interest and frankly still don’t....
I thought I was taking crazy pills watching people tell the guy not to join social media, on a social media site!
I think the real question being asked is, should the OP make a social media account that is not anonymous or on one of the mainstream sites. Which I would say go for it if it helps with your IRL social life, just don't post anything you wouldn't say in person in public.
I don't disagree that comment OP could have phrased it better and come across as less judgey. And I think that of someone like you left a well worded reply to the effect that it would be very fair feedback.
At the same time I feel like some of the comments she has gotten are living down to the less generous version of her statements. If that makes sense. It also sort of feels like people wallpapering over the underlying reason that many women look for social media participation, which is as a way to vet for safety reasons.
But I agree, it's not good to typecast and overgeneralize, and a better suggestion to the post OP might be that some women look for social media accounts for safety reasons, if that is part of your social issues mentioned.
I love that your post gave a probabilistic binning of someone who doesn't have a traditional social media account, which was unironically confirmed by people replying with rustled jimmies.
Come on folks, it should be clear from context that she is saying that a single woman setting up dates is going to use what limited info they have to avoid stalkers, cheaters, red pillers, and anti social people. That this might filter out perfectly normal people along with the creeps is the cost of maintaining safety and not wasting time, which is pretty much par for the course in dating. There's also a difference between exchanging info after a brief meeting, and actually knowing a person for an extended time and then dating. I doubt OP is saying that someone they studied with for three semesters would be excluded for lack of social media, because they have real life context and don't need the proxy filters.
Also, getting real close in these replies to "but I'm a nice guy" and "I'm not like other girls."
Right. Which gets us full circle, to never give investment advice, lol. That being said, at some point someone may sincerely look too you for guidance and you need to make a call as to whether you want to take that risk, what advice you give, and are you sure it is good advice.
I used to mentor student employees years ago, and when they wanted advice I always told them to max out workplace matches first, and then after that if they can save more, put it in tax advantaged savings programs that let you buy into indexed funds and never sell. In those cases you usually can't even sell unless certain conditions are met and you sign disclosures, unlike most brokerages. Now, students you are giving them advice for the rest of there life and they likely don't have $40k to panic sell/buy/sell to zero.
Honestly in my other comment I said never give investing advice, but as far as it goes, recommending investment in indexed funds is probably there exception with the caveat that it is a multi-year investment and there are dips.
Yes, times a thousand. But I would go even further.
Never give investment advice. You might explain what investments you have made and why you made them, but never give advice and never urge or prompt someone to invest. You should also end every conversation with "but that's not advice and I'm not an expert." It is too easy for either the investment to not work out, or for them to do it wrong (wrong timing, panic sale, misunderstood the options, etc).
The last thing you want on your conscience is someone investing a life changing amount of money just for it to go down in flames. I might invest $1000 in something that I think might pay off, tell someone they should invest, and next thing you know they drop in $40k and panic sell on a dip in two weeks, when I was planning to hold for five years. You never know.
Maybe it'll be the best year yet (startrek.website)
What is the deal with Palestine and Hamas?
For mental health reasons, I had taken myself out of most political topics. But lately there seems to be a surge of talk about Palestine and Hamas (forgive me if I spelled this wrong). I do know it’s something to do with land rights, but it also seems to be so much more at the same time. I’m not trying to start any fights. I...
10 months later bill revisits his spaghetti code. forgets absolutely everything and refuses to elaborate. this wouldn't have happened if Bill forgot to comment on his code (lemmy.world)
Scientists discover first new antibiotics in over 60 years using AI (www.euronews.com)
What system or method do you use for your monthly budget or personal finance?
What budgeting advice do you recommend? Money management method?
What phone do you sugest for your grandparents?
I got a task to buy a smart phone for my grandparents, they are not techsavy but they know how to use basic functions. Iam looking for an andoid because it has language pack i need. I dont need it to have lots of functions, onley a good camera and a big screen. Bonus points if it can be flashed with some kind of simplefied...
Why do you use the terminal?
Hi, everybody Recently, a guy noticed that I was using it and asked why? For me it because in Linux many things are done through the terminal because Linux has many different desktop environments...
Duo out here teaching me the essentials (lemmy.world)
Is it just my circle, or has it been a challenge getting into the Christmas/holiday spirit the last couple of years?
Sure, the first year (or two) of COVID were wretched, but most of those barriers have since cleared — yet I’m still struggling. I’ve noticed the same with a number of people within my family and neighbourhood....
Remember to tip your boss this new years eve (lemmy.world)
hmm rock (lemmy.world)
After a lifetime against, I'm considering joining social media. Any advice?
I’ve never had a Facebook account or any other social media. I know they keep shadow profiles, but I’ve never given permission. I never had any interest and frankly still don’t....
I'll be spending Christmas with Lemmy this year, thank you (lemmy.ca)
Guys/Gals it’s posted in the meme community, clearly this did not happen. The joke is funnier in the first person.