Framework. I’ve run Debian, Fedora and for a while now NixOS, all of which have worked flawlessly.
I did have to replace the heatsink/fan part on mine because the fan bearing started clicking, but I’m sure that was just a first generation product issue (I was one of the first batches). I was glad to be able to do the replacement myself at relatively low cost and the process couldn’t have been easier (took about 30 minutes).
My previous machine was a 2013-ish ThinkPad X series and the Framework absolutely blows it out of the water. I’m looking forward to upgrading mine to a Ryzen motherboard sometime in the not so distant future.
Every hour via Restic to a local Mino instance on my NAS. Once a day to backblaze B2. Once a week to an offline HDD in my fire safe.
Keep in mind the more often you backup the less total time each backup should take to run. If your backup software isn’t too heavy to run and stores backups incrementally, there is little penalty to frequent backups.