I really like the idea of changing settings midway through a show. A story would start in ancient China, then switch to the distant future (with the same characters, situation, and ongoing plot), then switch to WWII (same characters, etc), and so on.
I have no idea what kind of story would work with that kind of setting change, but I really like the idea.
And then I’d like to see the same kind of setting bouncing, but with the characters being aware of the switches, and trying to gain advantage through it. Kind of like Inception, but less terrible.