zosurabalpin doesn’t seem to work on any other Gram-negative bacteria besides A. baumannii. The proteins in the LPS transporter complex are not conserved across different bacteria. Thus, targeting the LPS transporters of other nefarious Gram-negative bacteria will take yet more drug development research. One bright side of this, as Gugger and Hergenrother note in their commentary, is that it may produce species-specific antibiotics, which could protect patients’ microbiomes from being obliterated by broad-spectrum drugs, which we now appreciate is bad for human health.
And, of course, with any new antibiotic, there’s the inevitability that bacteria will develop resistance. The researchers already found that select mutations in the LPS transporter machinery can knock back the drug’s potency. Also, A. baumannii doesn’t need LPS to stay alive. That said, simply blocking LPS production would leave A. baumannii more vulnerable, and it’s unclear how that trade-off will play out in clinical settings.
No, not really. It’s only a matter of time before they are resistant to this one too, and I don’t know that we can help it even if distribution antibiotics carefully.
A war like Ukraine or a Genocide like Gaza tends to speed up bacterial resistance a lot, while breakthroughs are rare. I don’t see anything in this article that says it will be more difficult for bugs to become resistant to it. All bugs evolve constantly.
Name me one thing humans have been 100% reponsible with, from nuclear weapons to airplanes. Especially when it comes to antibiotics, people are going to take what they have available.
Yeah, the sole reason I don’t have linux on my old laptop is that lenovo has completely proprietary video drivers for it. I’m talking “manufacturer’s installers don’t think there’s a video card there” proprietary.
Edit. By software I’m talking about in game features.
Like FSR and such? That’s available on Linux (FSR 1.x is integrated into SteamOS for compositor-level upscaling). AFAIK AMD does not officially support FSR on Linux but it’s written in a way that it should work with minor integration work. It’s written with cross-platform support in mind, given that it’s targeting PlayStation etc. als well.
Don’t misunderstand what a server means, however. Just because something is called a server doesn’t mean it’s not made for the desktop. It’s a technical term that doesn’t necessarily relate to networking, it might just relate to stuff like inter-process communication.
However, Wayland is designed for the desktop environment. It’s like the main reason why it replaces X11, which was designed for terminals.
My comment was mostly meant as a joke. I’m aware most of them use their networking capabilities for IPC and being able to use them remotely is just a cool feature resulting from that (except X11).
Linux is an everything OS with whatever features you want/need. Do you need a hardened enterprise server? Linux got you. Do you need a user friendly OS for even non-technical people? Linux got you. Do you need something that can do a little of everything? Believe it or not, Linux got you.
I know this is a joke comment but Linux is for sure an enterprise kernel first and foremost. It did not start that way but that is how it has been developed and managed for many years now. Maybe the most incorrect thing anybody has ever said on record in the computer industry is when Linus said Linux was “not going to be anything big and professional”.
Linux distributions, which are conceived and managed totally independently from the kernel are available for every niche. Many of them are desktop and “consumer” oriented. With many Linux distributions, I would say that it is more accurate that they are hobbiest oriented more than what Microsoft would mean be “consumer”.
embedded windows in the japanese arcade scene has been working fine so far. for example, most of bandais arcade machines in the past like 7 yaers or so basically run embedded windows.
it was a benefit to non arcade users because a majority of games that were on those machines eventually got pc versions, or a new game on pc for the first time (e.g Tekken 7, Taiko No Tatsujin), where historically, theyve basically never been on PC officially.
So let me get this straight – your defense of Microsoft, in this instance, is Japanese cabinet makers, making arcade machines, where the user doesn’t interact with the operating system in the slightest bit? A Japan that still faxes even in modernity? That’s your defense of MS? I bet they aren’t even using a special build of windows — just the desktop schlock with some shitty 3rd party app on top.
im not defending mocrosoft at a whole, im just saying windows embedded isnt as bad as you actually think it is, and consumers benefitted from it more than it not
A Japan that still faxes even in modernity?
what a country does has barely anything to do with rhis context. thats like saying the U.S is shit because they didnt have tap to pay until Covid happened, whoch other countries have been usong for a decade before, or having terrible public transportation and internet infrastructure, and in the latter case, basically invented it.
That’s your defense of MS? I bet they aren’t even using a special build of windows — just the desktop schlock with some shitty 3rd party app on top.
that shows how ignorant you are with it because all of the games arent directly ported. look into the efforts required to port Gundam Extreme Versus 2 on teknoparrot. if it was a native game, then they wouldnt have to jump through as many hoops as the game doesnt have a PC port (nor any of its predecessors have ever had one)
I don’t know that Microsoft has any business trying to make Windows support these devices better…
Windows is entirely built around two pillars:
Enterprise support for corporations, and team machine management
Entirely open compatibility so they can run almost any hardware you put into it, plug into it, and backwards compatibility for all that for as long as possible.
Portable game machines are not an enterprise product. Nor do you care about broad hardware support or upgradability. Nor do you care about plugging in your parallel port printer from 1985. Nor do you care about running your ancient vb6 code to run your production machines over some random firewire card.
Windows’ goal is entirely oppositional to portable gaming devices. It makes almost no sense for them to try to support it, as it’d go against their entire model. For things like these, you want a thin, optimized-over-flexible, purpose built OS that does one thing: play games. Linux is already built to solve this problem way better than Windows.
But, Microsoft will probably be stupid enough to try anyway.
How many actual PC handhelds are there?
The link in the article that promises “plenty” of handheld examples talks about Steam deck, Asus, and… the switch. And that’s it. And obviously the switch is not a PC handheld, so… ?
There’s quite a few. Steam deck and Asus, as you mentioned, but there’s also AyaNeo, GPD, OneXPlayer, Aokzoe, Lenovo, etc. And many of these brands have several different models, if you’re counting individual products.
Anecdotally, I have an Aya Neo. I know a few people with a few of the others brands. There’s a decently sized Aya Neo Discord that I’m part of, and I would assume the other brands have something similar. There’s definitely use of non-Steam handhelds, or there wouldn’t be a growing market for them.
I personally love it, and yes it can with a dock similar to the Switch’s. It’s ran every game I’ve thrown at it, and I’ve an original 2021 version. There’s a few quirks, like the joysticks will sometimes just decide to not do a random direction, but recalibrating is easy. Obviously the resolution quality isn’t as stellar as if you were running a pc meant output to a monitor, but on the built in screen everything is crispy. It’s decently heavy though, so my baby wrists get tired after a while. But yeah it’s great, playing whatever wherever is pretty ace.
Not sure what you mean – they all run Linux. The images just have the video hardware configs baked in with a preconfigured user and start script. You would be amazed at how easy that is to do, all things considered. I have a few kiosk configurations I created for the two Home Assistant panels I have in my house.
And, most importantly, money bags to subsidise the hell out of it. Let’s not kid ourselves here, the damn low price is one of the main reasons why people buy the SD rather than the ~2x more expensive alternatives.
Thank you for making your comment licensed under creative common. I’ll now steal it, repackage it and sell for 9.99$ without even acknowledging your existence
But… it’s a Non-commercial Attribution license. /s/ns
I’m joking, but on a more serious note for those that don’t know, not all Creative Commons licenses allow you to monetize, and be sure to actually read which version of license is used if you plan to use a CC work for anything other than personal use.
I don’t think linking to a licence that increases the rights of third parties to do things with your words (over the default all rights reserved) will do very much for you there.
I think you’re missing my point. You are giving people more rights to use your comments by putting them under CC licence than not putting them under any.
No, how was I supposed to infer that you were fine with non-commercial AI from your two letter response to why you were licencing your comment?
I think its fairly naive to think that linking to a licence will do anything to stop commercial AI but not open ones, but you go for it if you think it’s worthwhile.
You joke but when “media” outlets boldly steal 90% of their content directly from reddit posts and comments without attribution for commercial use, maybe including a license isnt crazy anymore?
i think they are already mentioning it: MS has a help webpage on how to install linux, both WSL2 on Windows machine, or how to burn iso and install linux on bare metal. learn.microsoft.com/en-us/linux/install
Microsoft have quite a bit of software that runs on Linux (PowerShell, VS Code, .NET, Azure tools, Intune / Endpoint Manager, even SQL Server) so it’s understandable that they’d have documentation to explain it to their customers.
Yep, they run it themselves even. Previously their motto was “Linux is a Cancer” now they have embraced it and developed their own distro (CBL). With how everything is going WebApp these days, I can see a day when Windows will be linux based kernel.
They already have a Windows version for a handheld. The Xbox runs a modified version of Windows 11. All they’d need to do to bring it in line with PC handhelds is allow the install of third party launchers (they probably wouldn’t do this though).
A bunch of them saw Valve say “We’re coming out with a gaming PC that vaguely resembles an adult Nintendo Switch” and went “uh yeah us too!” I know Asus and Lenovo have one.
Yeah AYANEO themselves confirmed it. It mentions HoloISO, although I think originally it didn’t and said SteamOS and some posts/comments etc did say otherwise due to that.
As much as I love my steam deck and the os, I do wish it was slightly easier to install third party games.
I know it’s not hard and I’ve installed plenty, but like it’s so incredibly easy with steam that it’s made me lazy to even install games I already have on gog
It’s not Linux or SteamOS, but both Epic and CD Projekt don’t support their store client apps and launchers on Linux sadly, such we have to use unofficial ones such as Heroic Game Launcher
Hasn’t Steam just beat its record of simultaneously online users? And while I’m sure Steam Decks contributed to this, we’re taking of numbers an order of magnitude bigger. Hell, PC gaming is doing so well that we’re seeing until then console exclusive games come out on Steam.
I think the problem is that it’s super popular for those who already own a PC and have a huge Steam Library. I got console friends wanting a Steam Deck but ultimately don’t want to buy one because it means rebuying their games.
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