Nah, you take your shot (without being inappropriate) then you accept the answer gracefully.
This guy did a three in one - she clearly went way, way beyond acceptable responses, but forcing out a straight “no” makes women uncomfortable.
When she says “I have a boyfriend” or “I’m gay” or whatever, it may be the reason she’s saying no or she might just be lying to spare your pride and avoid a bad reaction. An excuse is definitely a “no” though
You get one shot. If you’re the type who needs a clear answer, ask a clear question the first time