Markiplier said it himself that he wishes he could go back to having a small fanbase, not because he hates his fans, but because he feels like he cant have normal friendships with people now.
Did you know the bite force of a hippo is 1820 psi? For comparison, the bite force of a lion is 650 psi, which could easily crush your rib cage as it can only withstand 630 pounds of force.