If you think about average hotel construction, most are built similarly; bathroom right as you walk in, bed(s) further out, and a window. I’d wager this is due to keeping the plumbing more centralized to the building core, especially the waste pipes. If you ran the bathrooms to the outer edge of the building, that would increase the length of the plumbing laterals, more space between floors to accommodate greater slope of the waste pipes (and a greater risk of them becoming clogged), and reduced water pressure (without upsizing a pressure pump). It just becomes more economical to build this way, especially when you add a number of floors.
Indeed. The thing that threw me off there was that I’d imagine the increased water pressure in that room immediately flood the u-bend on the toilet, given that toilets flush when more water is added to the bowl.