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roguetrick, (edited ) to asklemmy in What are some small things we should change about the human body?

That's a complicated question, because yes there are weight loss drugs that mimic certain aspects of diabetes, but through different mechanisms of action. A good example is a SGLT2 inhibitor medication, which explicitly creates glycosuria in a non-diabetic person, which is kind of a defining feature of diabetes mellitus. While that's a generally very effective drug and should be used more for obesity control, it will also increase incidence of UTI and (due to a loss of sugar and thus forcing metabolism of fats/proteins) ketoacidosis.

The insulin/glucagon relationship is why diabetic ketoacidosis only shows up in type 1 diabetics and not type 2 (they get what's called hyperosmolar hyperglycemic state), and is an important part of liver fat production. Ketoacidosis is generally associated with that but is also present in starvation and alcoholics that don't eat actual food.

The greater point I was making wasn't about carbohydrates turning into fats. It's that most fats and about half of proteins cannot be turned into carbohydrates. They must be metabolized into ketones and then acetone. If you absorb them and cannot store them like in the OP's hypothetical, you'll end up having to immediately metabolize them and will end up with ketoacidosis.

roguetrick, (edited ) to asklemmy in What are some small things we should change about the human body?

It's all about degree. Essentially what I'm talking about is severe dysregulation of lipid/protein metabolism that is generally only seen in type 1 diabetics, but it's the natural extension of extreme lipid and protein metabolism. I'm not familiar with that supplement, however.

As far as you watching yourself for it, don't worry, you'd notice being acidotic. I've seen it plenty of times at the hospital and you'd be huffing and puffing the acid off with terrible stomach pain and be generally having a bad day. While that supplement is associated with urine acetone increases, it's not quite the degree that I'm taking about.

Essentially, inhibiting fat production and storage and eliminating it result in very different effects. Insulin, by the way, is a very important mediator in fat production and storage. It's why so many new diagnosis type 1 diabetic children are often underweight.

roguetrick, (edited ) to asklemmy in What are some small things we should change about the human body?

Only for half of protein and carbohydrates that can go into the gluconeogenesis pathway. That'll increase uti incidence, shred your kidneys with proteinurea, and lead to ketoacidosis when you're dealing with the other half of the proteins and all the other lipids, which before it kills you will allow you to excrete that waste from you lungs while you smell like you've been huffing nail polish remover. I think the out the butt option is generally preferable.

roguetrick, to asklemmy in What are some small things we should change about the human body?

You can waterboard them with it. If you want to effectively kill them, I'd recommend using the tried and true neurotoxin option sold at your local grocery store. You can be your own Saddam Hussein without having to hide in the most random places after committing your war crimes.

roguetrick, to asklemmy in What are some small things we should change about the human body?

Goddamn ear fuckers.

roguetrick, to asklemmy in What are some small things we should change about the human body?

While you can create spiracles that repel polar substances like water, you cannot protect them against surfactant like soap. No more showers unless you want to drown.

roguetrick, to asklemmy in What are some small things we should change about the human body?

Manual/deliberate control over fat creation and storage.

Monkey's paw on this one is that you'd end up having some pretty fantastic explosive diarrhea as the bacteria chow down on your energy loaded waste.

roguetrick, (edited ) to asklemmy in What are some small things we should change about the human body?

in which case penises would have to compensate I guess

Brother, if you're penetrating the cervix, you are doing it wrong.

roguetrick, to risa in I'm so confused right now 🤔

We have Miles O'Brien at home.

roguetrick, to science_memes in The dangers of doing science during a dry spell

I posted this directly after you were hornyposting about greek gods.

roguetrick, (edited ) to memes in friendly PSA: not all jews are white

That's a right winger position on the one state solution. I'm not implying that's the only position, but that's essentially the path Israel is walking down right now. The left wing one state solution is much less problematic.

roguetrick, (edited ) to memes in friendly PSA: not all jews are white

Free Palestine

You're missing one state solution. That's what's essentially going to happen as things go. They're depopulating gaza with the plan to eventually grant citizenship to the reduced population of Palestinians so they can maintain a jewish majority. West bank alone wouldn't cause a loss in majority, but Gaza would. They won't grant right of return. Though that is genocide.

roguetrick, to asklemmy in What's the best gaming console and why?

Intellivision because the controller has an insert with labels for what the buttons do for each game.

roguetrick, to asklemmy in What is Something Scientific that you just don't believe in at all?

I think the answer is complicated. Homo erectus, the first homo species thought to use fire and our direct ancestors were as close to obligate carnivores as there is in the homo genus, but they focused on big animals with a lot of fat like hippos and elephants. They likely did not cook that fat, because it would store just fine without doing so.

roguetrick, to science_memes in The dangers of doing science during a dry spell

Don't show this to stamets.

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