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roguetrick, (edited ) to asklemmy in What are some small things we should change about the human body?

That's a complicated question, because yes there are weight loss drugs that mimic certain aspects of diabetes, but through different mechanisms of action. A good example is a SGLT2 inhibitor medication, which explicitly creates glycosuria in a non-diabetic person, which is kind of a defining feature of diabetes mellitus. While that's a generally very effective drug and should be used more for obesity control, it will also increase incidence of UTI and (due to a loss of sugar and thus forcing metabolism of fats/proteins) ketoacidosis.

The insulin/glucagon relationship is why diabetic ketoacidosis only shows up in type 1 diabetics and not type 2 (they get what's called hyperosmolar hyperglycemic state), and is an important part of liver fat production. Ketoacidosis is generally associated with that but is also present in starvation and alcoholics that don't eat actual food.

The greater point I was making wasn't about carbohydrates turning into fats. It's that most fats and about half of proteins cannot be turned into carbohydrates. They must be metabolized into ketones and then acetone. If you absorb them and cannot store them like in the OP's hypothetical, you'll end up having to immediately metabolize them and will end up with ketoacidosis.

roguetrick, (edited ) to asklemmy in What are some small things we should change about the human body?

It's all about degree. Essentially what I'm talking about is severe dysregulation of lipid/protein metabolism that is generally only seen in type 1 diabetics, but it's the natural extension of extreme lipid and protein metabolism. I'm not familiar with that supplement, however.

As far as you watching yourself for it, don't worry, you'd notice being acidotic. I've seen it plenty of times at the hospital and you'd be huffing and puffing the acid off with terrible stomach pain and be generally having a bad day. While that supplement is associated with urine acetone increases, it's not quite the degree that I'm taking about.

Essentially, inhibiting fat production and storage and eliminating it result in very different effects. Insulin, by the way, is a very important mediator in fat production and storage. It's why so many new diagnosis type 1 diabetic children are often underweight.

roguetrick, (edited ) to asklemmy in What are some small things we should change about the human body?

Only for half of protein and carbohydrates that can go into the gluconeogenesis pathway. That'll increase uti incidence, shred your kidneys with proteinurea, and lead to ketoacidosis when you're dealing with the other half of the proteins and all the other lipids, which before it kills you will allow you to excrete that waste from you lungs while you smell like you've been huffing nail polish remover. I think the out the butt option is generally preferable.

roguetrick, to science_memes in The dangers of doing science during a dry spell

I posted this directly after you were hornyposting about greek gods.

roguetrick, to asklemmy in Can someone answer a nagging question i have about CRT?

I could only recommend an introductory college course since that's where I picked up the basics. Hopefully someone else has better resources. An important thing about sociology is understanding the different approaches there are to things and the language those approaches use.

roguetrick, (edited ) to asklemmy in Is society becoming more fake ?

Oh for sure. We already had complex social relationships that involved lying when we were only homo erectus and likely incapable of speech and were hunting full grown elephants and hippopotami(yeah, simple stone tools against those monsters required some serious teamwork). I think that creating a social face for those you DON'T know, though, had to come about once we were in a situation where there were people we interacted with that we didn't know. Hunter/gatherer societies generally still operated with too much of a cohesion for you to truly be "fake".

roguetrick, to historyporn in Woman strikes a Swedish neonazi with her handbag, 1985

Your nonsense almost makes me want to leave Kbin because even when you get banned on other communities instances I still have to read your nonsensical prattle about how you want to genocide Palestinians.

roguetrick, to upliftingnews in New Portable Water Treatment System Vaporizes 99% of ‘Forever Chemicals’

What do you with activated carbon? You bury it. It often comes from sustainable charcoal itself. It's actually GOOD for the environment.

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