The only time I’ve seen something like this is when my doctor really wanted me to try an anti-depressant, so he gave me a perpetual supply of free samples.
It depends on what you mean by “start working.” The first time I took a sertraline, I felt absolutely baked, but I feel like it took weeks for the desirable effects to take hold.
Then again, my doctor also told me that something like 60% of the effects are a placebo.
Regardless, yes, he would give me like a month of these individal samples at a time. I’m not sure how he swung that. It was like 2003 or 2004.
For classical antidepressants Chemicals tend to function pretty fast but the effect is designed to be subtle because you need to live a normal life, capable of dealing with and feeling both ups and downs. not be perpetually smiling or brain dead.
After some time “a few weeks” of taking a daily dose your body and mind adjust to the subtle changes causing a stable therapeutic effect. At least thats what I understand is the idea.
But lately there is also sm of a psychedelic renaissance of medicine and they work entirely different where a single dose within a therapeutic setting creates a longer lasting feeling of increased well being.
Nasal Ketamine seems to receive allot of attention, near instantly improving the condition. They tend to need 1 dose every 5 weeks so its less addictive then classic medicine. But i do admit it instant improvement for treatment resistant medications is a bold claim and still subject of more research.
The side effects can last for weeks. It’s like a really shitty onboarding process. For some, the side effects are not bad. Personally I can say that the first 2 to 4 weeks are usually filled with nausea, extreme fatigue and exhaustion.
The way that these sorts of meds have been described to me is that “they give you a leg up”, meaning it gives you just enough of a “boost” that you might actually follow through on therapy and the strategies it offers.
It has been years now, and still no luck. I’d love to live a normal life, whatever the fuck that means lol
A doctor said this and it was such a good metaphor: imagine that you have a 3000 year old machine (which no one understands anymore) with a bunch of cogs and gears, and you’re looking down at it from above. You’re trying to fix a gear that is slightly out of alignment further down in the machine, you can’t really tell which one it is but you know roughly which area, and to fix it you drop a rock into the machine and watch it fall down.
That’s what we’re doing with SSRIs. We’re dropping a rock that manipulates our serotonin, which gives a bunch of effects but not the one we’re after. The one we’re after is somewhere down the line. It’s affected by processes that are affected by the serotonin somehow. We’re not exactly sure which one it is, but we know that if we drop the rock in there it will make the gears align sooner or later.
Which is why it takes time, and why it has some odd effects on people sometimes.
edit: added a detail I missed, to make it clearer.
There’s other antidepressants that don’t do that. Mirtazapine for instance helps sleep, and has no real impact on sex. It’ll make you hungry, though. Buproprion will mess with your sleep but not sex, but you’ll have no appetite. They all have their own unique collection of side effects, well worth looking into other options if SSRI’s aren’t well tolerated
Friendly reminder that sexual side effects of SSRIs are incredibly common, some medications effect more than one in four, but it is something that’s typically wildly underreported unless the practitioner brings it up, specifically, first. Not just “any side effects”.
There are multiple treatment options for people who encounter those side effects. They can range from poor libido/drive, to inability to obtain an erection or adequate vaginal moisture, to delayed or absent orgasm. All are common and all are frustrating. All can occur alone or with one or more partners.
If it’s impacting treatment or quality of life or your ability to stay compliant with meds, it’s absolutely worth discussing with your provider. There are other medications or alternative schedules to taking SSRIs. There are other meds that can be prescribed alongside SSRIs to accommodate for the side effects.
I totally understand that this is a necessary process for anti depressants but damn it sounds scary as fuck. “Eat these brain chemicals and come back and see us in a couple weeks”
“How does it work?”
“Fuck if I know it’s kind of like throwing a rock at an old machine. Just make sure you let me know if you experience any of the long extensive list of potential side effects!” Like damn im for sure not a doctor but that sounds like russian roulette with brain pellets to me. If Ecstasy (which was invented by a pharmacutical company to be medication) can permanantly fuck up your brain I would bet money that these pills certainly do the same. I bite my tongue anytime someone mentions they are considering it or talking to a doctor about it, their choice. But man it scares the fuck out of me. Ill just continue to sleep all the time and stay angry lol
SSRIs definitely work for some people. It’s just that everyone’s brain chemistry is extremely different and complex. Doesn’t make it less scientific. Making the best guess is math and science.
I would say it even works for many people. We’re aware of the fact that it works, and we’re aware of the fact that it effects serotonin. We also know that serotonin isn’t what does the work. There’s something down the line that is affected by the processes of the body that just happens to react in the chain from the serotonin manipulation.
But all the other things that are affected in that chain can also do weird stuff to you if you’re unlucky. That’s why it’s important to have good communication with your physician during the process.
This is one thing where so many people I talk to got unlucky. For me, SSRIs were super lucky in that they helped alleviate depression caused by my anxiety which then helped me find other roots of the anxiety. Turns out undiagnosed ADHD is terrible for your anxiety - got diagnosed though!
Side effects for me have included stomach issues and weight not coming off even as my physical condition improves as I’ve started running again. I’ll take it for now until I start weaning off in the future. I wouldn’t say they were a lifesaver but they helped immensely.
I always recommend trying it if the doctor recommends it (and if you want it) even though I was unlucky and turned paranoid three pills in. I stopped taking them and it was over in a couple of days. So many people get helped by them and never say a word. People you and I wouldn’t ever assume were on them.
SSRIs were super lucky in that they helped alleviate depression caused by my anxiety which then helped me find other roots of the anxiety
You hit the nail on the head.
SSRIs are terrific at clearing some of the noise and making you more receptive to other therapy (namely talk therapy) and striking at the root of what’s causing the issue. I wouldn’t have even thought about talking to a therapist a year ago and it’s been revolutionary understanding my behaviors (especially those that I learned in childhood) and how I’m inadvertently passing them down to my kids.
Consequentially I’ve also been more aware of my wife’s behaviors and how she’s passing them down to the kids and she’s not quite as receptive to the criticism as I’ve been.
It really is eye opening to have a good long conversation about what’s troubling you with someone who understands the intricacies of how the mind works and how it pieces things together.
I’m in Canada, when I order pizza for my family of 3 it comes out to like $65+ with tax and delivery, it’s insane. Took them to burger king the other day, we got 3 meals and a couple of apple turnovers and it came out to $50+, shit is insane.
I generally order only when I can’t. Like when the day has been a hectic disaster, it’s 20 minutes from dinner, I haven’t had a chance to go to the store or cook, and the kids gotta eat. If it was just me alone I’d survive in crackers
Yeah. During the pandemic I realized fuck eating out. Why is the main public activity going to a fucking restaurant anyway? We need more museums. Like, lots more.
I will say tho, fast food salads (pick up not delivery) are worth it. I bought a $25 salad from a deli chain & said this is too expensive. So next week I spent $20 on salad ingredients & made a salad. I didn’t feel like a salad for a couple days & all ingredients wilted.
Maaan!! That’s crazy prices! Have you ever tried buying a frozen marg pizza and putting ur own toppings on. That’s what I do and it usually costs way less with minimal effort.
You gotta order online and use their apps and newsletters it can cut the price by half if not more. They are making their prices punitive for not using their apps now. Domino’s should be about $8 a pizza.
The first thing that jumped into my head was that meme about American couples where the couple is always Nice, Decently Attractive Woman Plus The Most Racist Man Alive. It’s the same dynamic.
If the Slavic women aren’t drinking, thus making them all on average prettier than the men because drink makes you ugly, then I fear for what they are actually doing instead. Probably cocaine.
Oh, I understood it; I’m a native English speaker. Unfortunately for you, “then dw bt it” doesn’t make any sense.
Are we even in a thread about AI? I’ve gone through my comments, and I don’t see any evidence of me being “obsessed with AI”, honestly it’s not that big of a deal to me.
Looks like someone’s projecting a little something…
who the fuck are you, pissing around in here like this? I wasn’t even replying to you. being a native english speaker honestly just adds to it. “if i cant understand it, it doesn’t make sense!” what an arrogant fucking moron. you realize how absolutely arrogant and narcissistic that sounds, right?
how about you post on your real account instead of your porn account so i can block bitter assholes like you. go get a lobotomy and get the fuck out my DMs
I’m not in your dms, but the only reason I’m on this account is that my normal ones were upgrading to 19.2 and my app hadn’t caught up lol. My normal accounts are @swab148 and @swab148 if you wanna block them.
Yes, it can. It can clog their gills, making their feeding less efficient, or interfere with their reproduction through chemicals that leach from the plastic particles. Source: I study bivalves
Ohh for sure, we can do that, you want just “AAAAAAAAAAAAAAAAAAARRRRHRHRHRHHHHHHHHHHHHHH” type of basic scream or you want it to go into specific details on where and how it hurts?
Both at the right decibel to not cause pain to the human listener, but loud enough to be heard at a distance.
Oysters actually need clean/unpolluted water. What they eat and clean is sediment, phytonutrients, and phytoplankton. Well at least that’s what I was tood by an oyster farmer. They clear the water which is good for the sea grass, and the small fish, which is good for the big fish and so on.
I saw a commercial on late night TV. It said, “Forget everything you know about slipcovers.” So I did. And it was a load off my mind. Then the commercial tried to sell me slipcovers, and I didn’t know what the hell they were.
I was advised once as a young man to travel there. It’s the place where the ratio of beauty between men and women is the furthest off kilter, and that an attractive American with a good job could find a woman with supermodel beauty.
Sounded creepy, never did it. If I go there it won’t be for that reason. Just wanted to add that someone in a mentor position to me advised it for that reason. Maybe there’s something to it
You can offset that by changing the feeding schedule. Just replenish the tank with gray water every other day instead of daily and you should be fine with only four.
Hard to say without knowing its composition. If rich in ammonium, the nitrification (oxidation to nitrate) might lead to lower alkalinity. If rich in nitrate, it might help alkalinity, but only if there’s some lower oxygen area of the tank like a bank of sediment, where denitrification can happen
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